| RuvB-like AAA ATPase 2 | OKDB#: 629 |
| Symbols: | RUVBL2 | Species: | human | ||
| Synonyms: | RVB2, TIH2, ECP51, TIP48, CGI-46, INO80J, REPTIN, TIP49B | Locus: | 19q13.3 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008] | ||||
| General function | Cell cycle regulation | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | Early embryo development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Oocyte | ||||
| Comment | Proteomic analysis of mouse oocytes reveals 28 candidate factors of the 'reprogrammome' Boiani M et al. The oocyte is the only cell of the body that can reprogram transplanted somatic nuclei, and sets the gold standard for all reprogramming methods. Therefore, an in-depth characterization of its proteome holds promise to advance our understanding of reprogramming and germ cell biology. To date, limitations on oocyte numbers and proteomic technology have impeded this task, and the search for reprogramming factors has been conducted in embryonic stem (ES) cells instead. Here, we present the proteome of metaphase II mouse oocytes to a depth of 3699 proteins, which substantially extends the number of proteins identified until now in mouse oocytes and is comparable by size to the proteome of undifferentiated mouse ES cells. Twenty-eight oocyte proteins, also detected in ES cells, match the criteria of our multi-level approach to screen for reprogramming factors, namely: nuclear localization, chromatin modification and catalytic activity. Our oocyte proteome catalog thus advances the definition of the 'reprogrammome', the set of molecules - proteins, RNAs, lipids and small molecules - that enable reprogramming. | ||||
| Follicle stages | |||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Jan. 31, 2000, midnight | by: |
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| last update: | Nov. 17, 2015, 3:14 p.m. | by: | hsueh email: |
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