Lysosomal acid
phosphatase, which is found in all tissues, played a pivotal role in the discovery of lysosomes. Like other lysosomal enzymes,
it contains mannose-6-phosphate residues that serve as a recognition marker for targeting to lysosomes.
NCBI Summary:
Lysosomal acid phosphatase is comprised of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.
General function
Metabolism, Enzyme, Hydrolase, Peptidase/Protease
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Follicle atresia, Luteolysis
Comment
Gregoraszczuk EL, et al 1997
studied lysosomal acid phosphatase activity and progesterone secretion
by porcine corpora lutea at various periods of the luteal phase.
The product of acid
phosphatase reaction indicated fewer lysosomes in the luteal cells of early developing
corpora lutea, increasing as luteal phase progressed. As the level of progesterone
declined in the terminal phase of the cycle, there was a maximal increase in the number
of lysosomes and enzyme activity. These events resulted in final regression of corpora
lutea.
Rosales-Torres AM et al 2000 studied mMultiparametric study of atresia in ewe antral follicles including histology,
flow cytometry, internucleosomal DNA fragmentation, and
lysosomal enzyme activities in granulosa cells and follicular fluid. Acid phosphatase and glucosaminidase in follicular fluid of 3-6 mm
follicles showed no significant modifications between healthy and initially atretic
follicles, and only a small, but significant increase in activity in advancedly atretic
follicles. On the contrary, lysosomal enzyme activity in follicles >6 mm showed
positive correlation between atresia stages and the activities of acid phosphatase and
glucosaminidase in follicular fluid.
Expression regulated by
FSH
Comment
Ovarian localization
Granulosa, Theca, Luteal cells
Comment
This gene was found in a rat ovarian cDNA library (Unigene)