Arylalkylamine N-acetyltransferase (NAT), together with
hydroxyindole-O-methyltransferase (HIOMT), are important in the biosynthesis of melatonin.
NCBI Summary:
Arylamine N-acetyltransferase 1; N- or O-acetylates arylamines and heterocyclic amines, detoxifies carcinogens and xenobiotics
General function
Metabolism, Enzyme, Transferase
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Comment
Expression regulated by
Growth Factors/ cytokines
Comment
Chang et al reported that intact human cumulus granulosa cells could acetylate arylamine
carcinogen (2-AF) and noncarcinogens drug (PABA). LIF decreased the NAT
activities. It provides a model for monitoring the effects of COH and LIF upon the
oocytes.
Ovarian localization
Granulosa
Comment
The presence of melatonin (N-acetyl-5-methoxytryptamine) and its precursors, serotonin
(5-hydroxytryptamine) and N-acetylserotonin, was demonstrated in extracts of human and rat ovaries by Itoh et al. (1997) and (1999) using reverse-phase high-performance liquid chromatography coupled with fluorometric detection. In addition, activities of two melatonin-synthesizing enzymes, arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), were found in human ovary homogenates.