Potassium channels are ubiquitous multisubunit membrane proteins that regulate membrane potential in numerous cell types.
One family of mammalian K+ channels is characterized by the presence of 4 transmembrane domains and 2 P domains per
subunit; this family includes TASK, TWIK (KCNK1) and TREK (KCNK2).
NCBI Summary:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
General function
Channel/transport protein
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Cellular localization
Plasma membrane
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Ovarian function
Unknown
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Expression regulated by
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Ovarian localization
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This gene was found in a rat ovarian cDNA library (Unigene)