| Tissue Factor Pathway Inhibitor | OKDB#: 740 |
| Symbols: | TFPI | Species: | human | ||
| Synonyms: | EXTRINSIC PATHWAY INHIBITOR, EPI|LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR, LACI|TFPI1 | Locus: | 2q31-q32.1 in Homo sapiens |
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| General Comment |
The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII with tissue factor, a
cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or
newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Once formed, the tissue
factor/factor VII complex converts to a complex of tissue factor and enzymatically active factor VII by an unknown
mechanism; this conversion leads to activation of factors X and IX and prothrombin, and ultimately to formation of fibrin.
These processes are regulated by plasma protease inhibitors and by the thrombomodulin-protein C pathway. A further
regulatory mechanism in the extrinsic pathway was proposed following discovery of a novel protease inhibitor called tissue
factor pathway inhibitor (TFPI) by Broze and Miletich (1987).
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| General function | Anti-apoptotic | ||||
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| Cellular localization | Secreted | ||||
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| Ovarian function | Unknown | ||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This gene was found in a rat ovarian cDNA library (Unigene) | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 31, 2000, midnight | by: |
uni email:
home page: |
| last update: | Feb. 5, 2009, 9:51 a.m. | by: | hsueh email: |
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