The mechanisms that govern the progression through the eukaryotic cell cycle consist of multiple regulatory processes that
control discrete transition points, such as the G0/G1 and G1/S transitions and the entry into mitosis. One of the key
components regulating the initiation and passage through mitosis is the serine/threonine-specific protein kinase,
p34(cdc2/CDC28); see 116953. There exists an extended gene family encoding a large number of different cdc2-related
serine/threonine-specific protein kinases. The PCTAIRE protein kinases comprise a distinct subfamily of these kinases and
are so named for the presence of a cysteine-for-serine substitution in the conserved PSTAIRE amino acid motif found in
prototypic cdc2 kinases. Three members of this kinase subfamily, PCTAIRE 1-3. Like other members of
the PCTAIRE subfamily, the predicted PCTAIRE2 protein contains an N-terminal extension relative to CDC2.
NCBI Summary:
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.
General function
Cell death/survival, Cell cycle regulation
Comment
Cellular localization
Nuclear
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Ovarian function
Unknown
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Expression regulated by
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Ovarian localization
Comment
This gene was found in a rat ovarian cDNA library (Unigene)