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General Comment |
In the rat, McPherson et al. (1996) found that synaptojanin is a nerve terminal protein of relative molecular mass 145,000 that appears to participate with dynamin in synaptic vesicle recycling. The central region of synaptojanin defines it as a member of the inositol-5-phosphatase family, which includes the product of the gene that is defective in the oculocerebrorenal syndrome of Lowe. Synaptojanin has 5-phosphatase activity, and its N-terminal domain is homologous with the yeast protein Sac1 (Rsd1), which is genetically implicated in phospholipid metabolism and in the function of the actin cytoskeleton. The C terminus, which is of different lengths in adult and developing neurons due to the alternative use of 2 termination sites, is proline-rich, consistent with the reported interaction of synaptojanin with the SH3 domains of GRB2.
NCBI Summary:
Synaptojanin 1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking.[supplied by RefSeq]
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