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Ovarian Kaleidoscope Database (OKdb)

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Matrin 3 OKDB#: 775
 Symbols: MATR3 Species: human
 Synonyms:  Locus:


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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link to BioGPS
General Comment Nuclear matrins are a group of proteins in the nuclear matrix, are present in cultured cells from a variety of tissues and are probably common to mammalian cells. This gene is FSH suppressed. Identification of differential gene expression in in vitro FSH treated pig granulosa cells using suppression subtractive hybridization. Bonnet A et al. ABSTRACT: FSH, which binds to specific receptors on granulosa cells in mammals, plays a key role in folliculogenesis. Its biological activity involves stimulation of intercellular communication and upregulation of steroidogenesis, but the entire spectrum of the genes regulated by FSH has yet to be fully characterized. In order to find new regulated transcripts, however rare, we have used a Suppression Subtractive Hybridization approach (SSH) on pig granulosa cells in primary culture treated or not with FSH. Two SSH libraries were generated and 76 clones were sequenced after selection by differential screening. Sixty four different sequences were identified, including 3 novel sequences. Experiments demonstrated the presence of 25 regulated transcripts. A gene ontology analysis of these 25 genes revealed (1) catalytic; (2) transport; (3) signal transducer; (4) binding; (5) anti-oxidant and (6) structural activities. These findings may deepen our understanding of FSH's effects. Particularly, they suggest that FSH is involved in the modulation of peroxidase activity and remodelling of chromatin.

NCBI Summary: The protein encoded by this gene is localized in the nuclear matrix. It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.
General function Cell organization, Chromosome organization
Comment
Cellular localization Nuclear
Comment
Ovarian function Unknown
Comment
Expression regulated by
Comment
Ovarian localization
Comment This gene was found in a rat ovarian cDNA library (Unigene)
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=29774
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created: Jan. 31, 2000, midnight by: uni   email:
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last update: July 19, 2006, 1:41 p.m. by: Alex    email:



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