The retinoblastoma (RB1) gene is one of the most extensively studied tumor-suppressor genes.
Loss of RB function is associated with loss of cellular proliferative
control; introduction of a wildtype RB can suppress cell growth and tumorigenicity. Woitach et al. (1998) described a
new gene, designated BOG (B5T overexpressed gene), which was shown to be overexpressed in several transformed
rat liver epithelial (RLE) cell lines resistant to the growth-inhibitory effect of TGF-beta-1 , as well
as in primary human liver tumors. The Bog protein was found to share homology with other retinoblastoma-binding
proteins and contained the RB-binding motif LXCXE. Using the yeast 2-hybrid system and coimmunoprecipitation, Woitach et al. (1998) demonstrated that Bog binds to the RB1 gene product. Overexpression of Bog in normal RLE
cells conferred resistance to the growth-inhibitory effect of TGF-beta-1. Furthermore, normal RLE cells were rapidly
transformed when Bog was continuously overexpressed and formed hepatoblastoma-like tumors when transplanted into
nude mice.
NCBI Summary:
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene encoding an identical protein have been reported.
General function
Nucleic acid binding, DNA binding, Transcription factor
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Cellular localization
Nuclear
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Ovarian function
Unknown
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Expression regulated by
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Ovarian localization
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This gene was found in a rat ovarian cDNA library (Unigene)