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Ovarian Kaleidoscope Database (OKdb)

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Triosephosphate Isomerase 1 OKDB#: 811
 Symbols: TPI1 Species: rat
 Synonyms: TPI| TRIOSEPHOSPHATE ISOMERASE DEFICIENCY, INCLUDED|  Locus: 12p13 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Metabolism, Enzyme
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Unknown
Comment
Expression regulated by
Comment
Ovarian localization Cumulus, Granulosa
Comment Oocyte control of metabolic cooperativity between oocytes and companion granulosa cells: energy metabolism Sugiura K, et al 2005 . Intercellular communication between oocytes and granulosa cells is essential for normal follicular differentiation and oocyte development. Subtraction hybridization was used to identify genes more highly expressed in cumulus cells than in mural granulosa cells of mouse antral follicles. This screen identified six genes involved in glycolysis: Eno1, Pkm2, Tpi, Aldoa, Ldh1, and Pfkp. When oocytes were microsurgically removed from cumulus cell-oocyte complexes, the isolated cumulus cells exhibited decreased expression levels of genes encoding glycolytic enzymes, glycolysis and activity of the tricarboxylic acid (TCA) cycle. These decreases were prevented by culturing the cumulus cells with paracrine factors secreted by fully grown oocytes. Paracrine factors from fully grown oocytes exhibited greater ability than those from growing oocytes to promote expression of genes encoding glycolytic enzymes and glycolysis in the granulosa cells of preantral follicles. However, neither fully grown nor growing oocytes secreted paracrine factors affecting activity of the TCA cycle. These results indicate that oocytes regulate glycolysis and the TCA cycle in granulosa cells in a manner specific to the population of granulosa cells and to the stage of growth and development of the oocyte. Oocytes control glycolysis in granulosa cells by regulating expression levels of genes encoding glycolytic enzymes. Therefore, mouse oocytes control the intercellular metabolic cooperativity between cumulus cells and oocytes needed for energy production by granulosa cells and required for oocyte and follicular development.
Follicle stages Antral
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
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http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=37838
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created: Jan. 31, 2000, midnight by: uni   email:
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last update: Feb. 16, 2005, 5:39 p.m. by: hsueh    email:



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