| Purinergic receptor P2X2 | OKDB#: 834 |
| Symbols: | Purinergic receptor P2X2 | Species: | human | ||
| Synonyms: | P2X RECEPTOR, SUBUNIT 2, P2X2| | Locus: | HPMR |
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| General Comment |
ATP is known to depolarize sensory neurons and may play a role in nociceptor activation when released from damaged tissue. Cell surface ATP receptors can be divided into 2 classes. The ionotropic (P2X) class are ligand-gated channels. The metabotropic (P2Y/P2U) class are members of the 7-transmembrane superfamily of G protein-coupled receptors Mammalian P2X receptors belong to a multigene family of nonselective cation channels activated by extracellular ATP.
NCBI Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. |
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian localization | |||||
| Comment | Bardini M et al reported that P2X(2) immunoreactivity in smooth muscle was present in ovary and uterus as well as in blood vessels. P2X(5) receptors were seen in the very early stages of ovarian follicular development; P2X(6) receptors were present in secondary follicles. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Feb. 13, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Aug. 14, 2001, 9:11 a.m. | by: | wilhelm email: |
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