ATP is known to depolarize sensory neurons and may play a role in nociceptor activation when released from damaged tissue. Cell surface ATP receptors can be divided into 2 classes. The ionotropic (P2X) class are ligand-gated channels. The metabotropic (P2Y/P2U) class are members of the 7-transmembrane superfamily of G protein-coupled receptors Mammalian P2X receptors belong to a multigene family of nonselective cation channels activated by extracellular ATP. Le et al. (1997) identified a human fetal brain cDNA related to the rat P2X5 gene.
NCBI Summary:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
Oogenesis, Oocyte maturation
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Gene whose expression is detected by cDNA array hybridization: transcription factors, cell signaling and extracellular communication Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
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Ovarian localization
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Bardini M et al reported that P2X(2)
immunoreactivity in smooth muscle was present in ovary and uterus as well as in blood vessels. P2X(5) receptors were seen in the very early
stages of ovarian follicular development; P2X(6) receptors were present in secondary follicles.