| Connective tissue growth factor-like | OKDB#: 838 |
| Symbols: | Connective tissue growth factor-like | Species: | human | ||
| Synonyms: | Locus: |
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R-L INTERACTIONS MGI |
| General Comment |
Kumar S, et al identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from
primary human osteoblast cells encoding a 250-amino acid single chain polypeptide. Murine CTGF-L
cDNA, encoding a polypeptide of 251 amino acids, was obtained from a murine lung cDNA library.
CTGF-L protein bears significant identity ( approximately 60%) to the CCN (CTGF, Cef10/Cyr61, Nov)
family of proteins. CTGF-L is composed of three distinct domains, an insulin-like growth factor binding
domain, a von Willebrand Factor type C motif, and a thrombospondin type I repeat. However, unlike
CTGF, CTGF-L lacks the C-terminal domain implicated in dimerization and heparin binding.
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| General function | Hormone | |||
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| Cellular localization | Secreted | |||
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| Ovarian function | ||||
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| Expression regulated by | ||||
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| Ovarian localization | ||||
| Comment | Kumar S, et al reported that CTGF-L mRNA ( approximately 1.3 kilobases) is expressed in primary human osteoblasts, fibroblasts, ovary, testes, and heart. | |||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | Feb. 14, 2000, midnight | by: |
Hsueh email:
home page: |
| last update: | March 28, 2004, 4:29 p.m. | by: | wilhelm email: |
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