The products of at least 11 maternal effect genes have been shown to be essential for proper germ plasm
assembly in Drosophila melanogaster embryos. Here we report the isolation and characterization of the
mammalian counterpart for one of these genes (named MAGOH for mago nashi homologue). The
predicted amino acid sequence of mouse and human MAGOH are completely identical; MAGOH
homologues from the nematode Caenorhabditis elegans and rice grain Oryza sativa also show a
remarkable degree of amino acid conservation. MAGOH was mapped to chromosome 1p33-p34 in the
human and a syntenic region of chromosome 4 in the mouse. Of note, MAGOH mRNA expression is not
limited to germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum
stimulation of quiescent fibroblasts.
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NCBI Summary:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq]
General function
Comment
mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in
Drosophila.
Development. 1997 Aug;124(16):3197-207.
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The mago nashi gene is required for the polarisation of the oocyte and the formation of
perpendicular axes in Drosophila.
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mag-1, a Homolog of Drosophila mago nashi, Regulates Hermaphrodite Germ-Line Sex
Determination in Caenorhabditis elegans.
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MAGOH is the human homologue of Drosophila mago nashi, a protein that is required for normal germ
plasm development in the Drosophila embryo. Using human MAGOH as a bait protein in a yeast
two-hybrid screen, we recovered four independent cDNA clones that encode different lengths of a novel
protein containing a ???????conserved RNA-binding region.
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