Cyclophilin is a specific high-affinity binding protein for the immunosuppressant agent cyclosporin A. Because of its
dramatic effects on decreasing morbidity and increasing survival rates in human transplants, the molecular mechanism of
immunosuppression by cyclosporin A has been a matter of much interest. Friedman and Weissman (1991) cloned a third cyclophilin from a cDNA library prepared from a
murine bone marrow-derived stromal cell line. Their initial interest in the cDNA was based on its high level of homology
with all known cyclophilins.
General function
Apoptosis, Enzyme, Isomerase
Comment
Cyclophilin A (also designated peptidyl-prolyl cis-trans isomerase A or PPIA) is a member of the immunophilin class of
proteins that all possess peptidyl-prolyl cis-trans isomerase activity and, therefore, are believed to be involved in protein
folding and/or intracellular protein transport.
Cellular localization
Comment
Ovarian function
Comment
Cyclophilin C (cyp C) is a cyclosporin A (CsA) binding protein originally isolated from a mouse bone
marrow stromal cell line. Friedman J, et al compared the expression patterns of the mammalian cyclophilins A, B,
and C in mouse tissues using in situ hybridization. These studies reveal that cyp C is expressed in a restricted
subset of tissues including mouse ovary, testis, bone marrow, and kidney.
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Primordial
Comment
Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.