The chemokines are structurally related proteins that act as chemoattractants and activators of lymphocytes and
phagocytes. Kozak et al. (1995) noted that there are 2 separate families of chemokines differentiated by the location of
the first 2 of 4 conserved cysteine residues. The alpha family is distinguished by the fact that the first 2 cysteines are
separated by a single amino acid (CXC), while in the beta family the cysteines are adjacent (CC).
Using degenerate oligonucleotide-based reverse transcriptase PCR, Power et al. (1997) cloned cDNAs encoding human
CMKBR6. Expression studies showed that CMKBR6 is the receptor for MIP-3-alpha (OMIM 601960) and its activation leads
to phospholipase C-dependent intracellular Ca2+ mobilization. Similarly, Liao et al. (1997) found that MIP-3-alpha is
the only chemokine that produces a calcium flux in CMKBR6-transfected cells.
NCBI Summary:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
General function
Receptor
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Oogenesis
Comment
The ligand for this receptor is exodus Wong et al 2002 . This is the receptor for CCL20.
Expression regulated by
Comment
Ovarian localization
Oocyte
Comment
Neilson L, et al 200 reported molecular phenotyping of the human oocyte by PCR-SAGE.
Consecutive application of PCR and serial analysis of gene expression (SAGE) was used to generate a
catalog of approximately 50,000 SAGEtags from nine human oocytes. Matches for known genes were
identified using the National Institutes of Health SAGEtag database. Matches in the oocyte SAGE catalog
were found for surface receptors, second-messenger systems, and cytoskeletal, apoptotic, and secreted
proteins, including the CCR6 gene decribed here.
Follicle stages
Comment
Phenotypes
Mutations
1 mutations
Species: mouse
Mutation name: type: null mutation fertility: fertile Comment: C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Reboldi A et al. (2009) Interleukin 17-producing T helper cells (T(H)-17 cells) are important in experimental autoimmune encephalomyelitis, but their route of entry into the central nervous system (CNS) and their contribution relative to that of other effector T cells remain to be determined. Here we found that mice lacking CCR6, a chemokine receptor characteristic of T(H)-17 cells, developed T(H)-17 responses but were highly resistant to the induction of experimental autoimmune encephalomyelitis. Disease susceptibility was reconstituted by transfer of wild-type T cells that entered into the CNS before disease onset and triggered massive CCR6-independent recruitment of effector T cells across activated parenchymal vessels. The CCR6 ligand CCL20 was constitutively expressed in epithelial cells of choroid plexus in mice and humans. Our results identify distinct molecular requirements and ports of lymphocyte entry into uninflamed versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS.//////////////////