BAD is Bcl-2-associated Death promoter ubiquitiously expressed in a wide range of tissues. The protection against apoptosis provided by growth factors in several cell lines is due to stimulation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway, which results in the activation of protein kinase B (PKB; also known as c-Akt) and phosphorylation of BAD. Bad phsophorylation leads to its sequestration by 14-3-3 proteins. BAD bound to 14-3-3 is devoid of the proapoptotic effect.
NCBI Summary:
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
General function
Cell death/survival, Apoptosis
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Follicle atresia, Oogenesis, Oocyte maturation
Comment
Genes whose expression is detected by cDNA array hybridization: GDP/GTP exchangers, GTPase stimulators and inhibitors, apoptosis Rozenn Dalbi?Tran and Pascal Mermilloda