ATP is known to depolarize sensory neurons and may play a role in nociceptor
activation when released from damaged tissue. Cell surface ATP receptors can be
divided into 2 classes. The ionotropic (P2X) class are ligand-gated channels. The
metabotropic (P2Y/P2U) class are members of the 7-transmembrane superfamily of G
protein-coupled receptors
The G-protein-coupled P2Y purinoceptors mediate a variety of physiological effects in response to
extracellular nucleotides. With the recent discovery of several new members from a variety of
species, the P2Y purinoceptor family now encompasses types P2Y1 to P2Y6.
NCBI Summary:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.
General function
Receptor
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Follicle development, Antral follicle growth
Comment
Janssens R, et al 2000 reported cloning and tissue distribution of the human P2Y1 receptor. Northern blot analysis detected a 6.7 kilobase
messenger RNA in most human tissues, the strongest signals being observed in prostate and ovary.