Bone morphogenetic proteins (BMP) belong structurally to the transforming growth factor-beta superfamily. BMP's were originally identified by their presence in bone-inductive extracts of demineralized bone. Similar to other family members, BMP-3 was shown to be expressed in several tissues during development including osteoblasts, kidneys and lungs (Vukicevic et al, 1994). NCBI Summary:
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation.
General function
Ligand, Growth factor
Comment
BMP-3 was shown to inhibit proliferation and stimulate differentiation of osteoprogenitors in human bone marrow (Amedee et al, 1994).
Cellular localization
Secreted
Comment
Ovarian function
Comment
Takao M, et al reported that BMP-3b transcripts
were predominantly expressed in cerebellum. BMP-3 mRNA was found in femur, calvaria, trachea,
lung and ovary. Although BMP-3b and BMP-3 are very closely related to each other, their transcripts
are distributed in different tissues except that both are found in bone.
Expression regulated by
LH
Comment
Time-dependence studies showed a clear decrease of BMP-3 mRNA levels in human granulosa-luteal cells after 24 h of culture with hCG treatment. This effect of hCG was concentration dependent. Furthermore, the cAMP analog, 8-bromo-cAMP (8-Br-cAMP), which activates protein kinase-A, and 12-0-tetradecanoylphorbol 13-acetate, an activator of protein kinase-C, both markedly decreased BMP-3 mRNA levels in an 8-h treatment (Jaatinen et al., 1996).
Ovarian localization
Granulosa
Comment
Jaatinen et al., 1996. studied the potential expression of BMP-2, -3, and -4 messenger RNAs (mRNAs) in isolated human granulosa cells obtained at oocyte retrieval for in vitro fertilization. Freshly isolated granulosa cells were found to express BMP-3 mRNAs but not those of BMP-2 or -4.
Follicle stages
Comment
Phenotypes
Mutations
1 mutations
Species: None
Mutation name: BMP-3 null
type: null mutation fertility: unknown Comment:Daluiski et al., 2001 generated BMP-3 mutant mice by targeted deletion. Viable adults were obtained with a novel skeletal phenotype. Influence on fertility unknown.