| Fucosidase, Alpha-l, 2 | OKDB#: 941 |
| Symbols: | FUCA2 | Species: | human | ||
| Synonyms: | ALPHA-L-FUCOSIDASE 2| FUCOSIDASE, ALPHA-L, PLASMA| FUCOSIDASE, PLASMA. LOW, INCLUDED| | Locus: | 6q25-qter in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Alpha-L-fucosidase (EC 3.2.1.51 ) catalyzes the hydrolysis of terminal alpha-L-fucosidase linkages in
glycosphingolipids and glycoproteins.
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| General function | Apoptosis | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Expression regulated by | Steroids | ||||
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| Ovarian localization | Granulosa | ||||
| Comment | Robert A Mastroeni, Deborah M Sindoni, Dana M Banas, Georgius de Haan, Donald E Frail, Susan L Fitzpatrick reported the identification and Characterization of Osteopontin and Other Estrogen Regulated Genes in Rat and Mouse Granulosa Cells In Vivo. By the use of Rapid Analysis of Differential Expression, a type of differential display, genes that were regulated by 17b-estradiol (E2) in vivo (1.5 mg daily for 3 days) were identified in granulosa cells from immature rats. Fucosidase mRNA expression was up regulated approximately 5-fold whereas osteopontin (OPN), osteoprotegerin, and aldehyde dehydrogenase mRNAs were down regulated approximately 5-fold. These results were confirmed by Northern blot analysis and/or quantitative RT-PCR. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | May 31, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Aug. 13, 2001, 3:16 p.m. | by: | hsueh email: |
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