Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only
known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the
intermediate junctions.
NCBI Summary:
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
General function
Cell adhesion molecule
Comment
Cellular localization
Secreted, Plasma membrane
Comment
Ovarian function
Luteinization
Comment
Expression regulated by
Comment
Ovarian localization
Luteal cells
Comment
Khan-Dawood FS et al 1996 reported immunocytochemical localization and expression of E-cadherin,
beta-catenin, and plakoglobin in the baboon (Papio anubis)
corpus luteum.
E-cadherin was localized to the
peripheral cell membranes of luteal cells at all stages examined, except atretic corpora lutea, with the
strongest immunoreactivity in the early luteal phase. Both beta-catenin and plakoglobin were localized in
the cytoplasm of the luteal cells. Immunoreactivity for all three peptides was not observed in nonluteal
tissue. By Western analysis, abundant expression of E-cadherin was observed in the early luteal phase,
and the level of expression was significantly different from that observed in the mid- and late luteal
phase corpora lutea. In contrast, the levels of beta-catenin and plakoglobin were higher in the midluteal
phase compared to the early luteal phase.