Li M et al 1997 reported expression of urokinase-type plasminogen activator and its receptor during ovarian follicular development.Atiomo WU, et al reported the plasminogen activator system in women with polycystic
ovary syndrome.
Johnson et al 1997 reported the expression of avian urokinase and tissue-type plasminogen activator messenger
ribonucleic acid during follicle development and atresia.
Expression regulated by
FSH, LH
Comment
Ovarian localization
Granulosa, Theca
Comment
Liu et al 1987 reported the gonadotropin regulation of tissue-type and urokinase-type plasminogen activators
in rat granulosa and theca-interstitial cells during the periovulatory period.
Follicle stages
Secondary, Antral, Preovulatory
Comment
Phenotypes
Mutations
1 mutations
Species: mouse
Mutation name: None
type: null mutation fertility: subfertile Comment: Ny A, et al reported that studies on mice lacking plasminogen activator gene function suggest that plasmin
production prior to ovulation exceeds the amount needed for optimal ovulation
efficiency.
Leonardsson G et al 1995 reported that ovulation efficiency is reduced in mice that lack plasminogen activator gene
function: functional redundancy among physiological plasminogen activators.
Hagglund et al 1996 reported coordinated and cell-specific induction of both physiological plasminogen
activators creates functionally redundant mechanisms for plasmin formation during
ovulation.