The RUSH transcription factors 1alpha and 1 bind to the Rabbit Uteroglobin promoter and are members of the SWI/SNF
complex that facilitates transcription by remodeling chromatin (Helicase).
General function
Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization
Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Granulosa, Theca
Comment
Rendon A, et al 2000 reported that RUSH was expressed in presumptive granulosa cells of embryonic and neonatal ovaries before follicle
organization. Abundant RUSH mRNA was detected in granulosa and theca cells surrounding preantral follicles of
prepubertal and adult ovaries. Expression of RUSH remained high in granulosa cells of antral follicles in mature
ovaries but was negligible in late-stage atretic follicles and in corpora lutea. Western blot analysis confirmed the
RUSH-1 isoform predominated in both testicular and ovarian tissues.