| Glucosamine 6-phosphate Deaminase | OKDB#: 981 |
| Symbols: | GNPI | Species: | human | ||
| Synonyms: | OSCILLIN, HAMSTER, HOMOLOG OF| | Locus: | 5q31 in Homo sapiens |
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| General Comment |
It was reported that a hamster protein, called ''oscillin,'' with a sequence related to that of an Escherichia coli GNPDA triggered Ca2+ oscillations in
mammalian oocytes when introduced into their cytoplasm upon fertilization.
GNPDA/oscillin is ubiquitously expressed in rat tissues and that a recombinant hamster GNPDA/oscillin protein does not exhibit oscillin activity when injected into oocytes.
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
| Comment | Amireault P, et al 2000 reported the cloning, sequencing, and expression analysis of mouse glucosamine-6-phosphate deaminase (GNPDA/oscillin). They reported the molecular cloning and sequencing of mouse GNPDA/oscillin, which shows over 96% identity with the hamster and human homologs. GNPDA/oscillin mRNA is detected in unfertilized oocytes and in all tissues examined including testis, heart, thymus, liver, ovary, uterus, kidney, spleen, and lung. The protein itself is also detected in all tissues examined by Western blots. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 27, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Aug. 13, 2001, 3:27 p.m. | by: | hsueh email: |
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