Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the
gallbladder.
CCK peptides exist in multiple molecular forms (e.g., sulfated CCK8, unsulfated CCK8, and CCK4), each resulting from
distinct posttranslational processing of the CCK gene product.
NCBI Summary:
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
General function
Ligand, Hormone
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Cellular localization
Secreted
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Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome. Hirschberg AL et al. (2004) Increased amount of abdominal fat and obesity are common in polycystic ovary syndrome (PCOS). A higher prevalence of bulimia nervosa and greater cravings for sweets have also been reported in these patients. The present study aimed to compare meal-related appetite and secretion of the 'satiety peptide' cholecystokinin (CCK) and glucose regulatory hormones in PCOS women and controls. Sixteen pairs of women with PCOS and controls matched for age and body mass index participated in the study. After an overnight fast, blood samples were collected during ingestion of a standardized meal. We determined basal and postprandial blood levels of CCK, insulin, C-peptide, glucagon, cortisol, growth hormone and glucose. Self-ratings of appetite were assessed by a visual analog scale. PCOS women had a significantly lower meal-related CCK response (p < 0.05) with no association with satiety, as in the controls (r = 0.64). There was a tendency to higher ratings of craving for sweets in PCOS women (p = 0.07) but no correlation with insulin, as in the controls (r = 0.50). Within the PCOS group, ratings of craving for sweets were inversely related to testosterone (r = - 0.60) and the CCK response was positively correlated with levels of free testosterone (r = 0.50). We conclude that women with PCOS have reduced postprandial CCK secretion and deranged appetite regulation associated with increased levels of testosterone. Impaired CCK secretion may play a role in the greater frequency of binge eating and overweight in women with PCOS.//////////////////
Ovarian function
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Expression regulated by
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Ovarian localization
ovarian nerves
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McNeill DL, et al 1987 reported the peripheral pathways for neuropeptide Y- and cholecystokinin-8-immunoreactive nerves innervating
the rat ovary.
Doss DN, et al 2000 reported the localization of cholecystokinin immunoreactivity in the rat ovary and uterine
tube.
The presence of cholecystokinin (CCK) immunoreactive nerve fibres in the rat ovary and uterine tubes
was detected using the peroxidase antiperoxidase (PAP) technique. The antibody used was anti CCK
4562 which reacts with CCK-4, CCK-8, CCK-12 and CCK-33 (Larsson and Rehfeld, 1977).
CCK-immunoreactive nerve fibres were found between the interstitial cells of the ovary, along blood
vessels, and close to smooth muscle fibres in the ovary and tubal wall.