The cholecystokinin (CCK) family of peptides and their receptors are widely distributed throughout the central
nervous system and gastrointestinal tract. The receptors can be divided into 2 subtypes on the basis of their affinity for
nonsulfated analogs of CCK. Type A receptors, which have a high affinity only for sulfated CCK-8, are found principally in
the gastrointestinal tract and select areas of the CNS, while type B (gastrin) receptors, having a high affinity for both sulfated
and nonsulfated CCK analogs, are found principally in the CNS and select areas of the gastrointestinal tract.
NCBI Summary:
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
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Lay JM, et al 2000 reported that mouse Cckb receptor
transcripts were most abundant in brain and stomach, but were also detected in colon, kidney, ovary,
and pancreas.