| KE6, MOUSE, HOMOLOG OF | OKDB#: 997 |
| Symbols: | KE6, MOUSE, HOMOLOG OF | Species: | human | ||
| Synonyms: | HKE6| D6S2245E| 3-@OXOACYL-ACYL CARRIER PROTEIN REDUCTASE, E. COLI, HOMOLOG OF| FABG, E. COLI, HOMOLOG OF, FABGL| | Locus: | 6p21.3 in Homo sapiens |
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| General Comment |
The abnormal regulation of the Ke6 gene, which is located within the major histocompatibility complex, has been linked to
the development of recessive polycystic kidney disease in the mouse.
Fomitcheva et al. (1998) showed that mouse Ke6 is a 17-beta-hydroxysteroid dehydrogenase (see HSD17B4) and
can regulate the concentration of biologically active estrogens and androgens. The Ke6 enzyme is preferentially an oxidative
enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity
and can synthesize estradiol from estrone.
NCBI Summary: In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. |
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| General function | Enzyme, Oxidoreductase | ||||
| Comment | |||||
| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | Steroid metabolism | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Cumulus | ||||
| Comment | Ke 6 gene is expressed within the ovaries and testes. The presence of Ke 6 protein within the cumulus cells surrounding the oocyte places it in a strategic location to control the level of steroids to which the egg is exposed. Fomitcheva J et al | ||||
| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | July 8, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Nov. 4, 2003, 3:13 p.m. | by: | hsueh email: |
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